2011•Chemistry - A European JournalRequires access
N‐Acetylmethionine and Biotin as Photocleavable Protective Groups for Ruthenium Polypyridyl Complexes
Roosmarijn E. Goldbach, Isabel Rodriguez‐Garcia, Joop H. van Lenthe, Maxime A. Siegler, Sylvestre Bonnet
Open publisher page 88 citations
Abstract
Ru in a new light! A potentially biologically active aqua complex can be “hidden” by S-coordination of N-acetylmethionine or biotin to ruthenium. Thus, the ruthenium–thioether complex appears as a prodrug, which can be “activated” by visible-light irradiation (see scheme). The biologically harmless thioether ligand therefore acts as a protecting group for the aqua–ruthenium complex.