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2004•Protein and Peptide LettersRequires access

Neprilysin 2: A Novel Messenger Peptide-Inactivating Metalloprotease

Tanja Ouimet

Open publisher page 4 citations

Abstract

Neprilysin 2 is a recently identified glycoprotein displaying the highest degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 family of zinc-dependent metalloproteases. Whereas neprilysin has been shown to be involved in the inactivation of endogenous messenger peptides, like enkephalins and tachykinins, the true physiological functions of neprilysin 2 remain unknown. Keywords: neprilysin, neprilysin 2, m13 family of metalloproteases, peptide inactivation, enkephalin, substance p, thiorphan, phosphoramidon

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What this paper is about

Neprilysin 2 is a recently identified glycoprotein displaying the highest degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 family of zinc-dependent metalloproteases. Whereas neprilysin has been shown to be involved in the inactivation of endogenous messenger peptides, like enkephalins and tachykinins, the true physiological functions of neprilysin 2 remain unknown. Keywords: neprilysin, neprilysin 2, m13 family of metalloproteases, peptide inactivation, enkephalin, substance p, thiorphan, phosphoramidon

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Available abstract

Neprilysin 2 is a recently identified glycoprotein displaying the highest degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 family of zinc-dependent metalloproteases. Whereas neprilysin has been shown to be involved in the inactivation of endogenous messenger peptides, like enkephalins and tachykinins, the true physiological functions of neprilysin 2 remain unknown. Keywords: neprilysin, neprilysin 2, m13 family of metalloproteases, peptide inactivation, enkephalin, substance p, thiorphan, phosphoramidon

Key concepts: Neprilysin, Phosphoramidon, Thiorphan, Enkephalinase, Metalloproteinase, Chemistry, Enkephalin, Peptide

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