1969•Scandinavian Journal of GastroenterologyRequires access

Effects of Gastrin on Acid and Pepsin Secretion in Pylorus-Ligated Rats

M Mignon, L. S. Semb, T. Lloyd Fletcher, Henry N. Harkins, Lloyd M. Nyhus

Abstract

Upon subcutaneous injection, gastrin extracts prepared from hog antral mucosa stimulated both acid and pepsin secretion in pylorus-ligated rats. However, as the dose of subcutaneous gastrin was raised to supramaximal levels, acid secretion remained stimulated, but pepsin secretion was depressed. Intravenous injection of gastrin extracts had no effect on acid secretion, but stimulated pepsin.

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Key concepts: Pepsin, Gastrin, Pylorus, Secretion, Internal medicine, Gastric acid, Endocrinology, Chemistry