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Stimulatory Effect of Aminoglutethimide on Phenylethanolamine-N-methyl Transferase (PNMT)1

William C. Duckworth, Abbas E. Kitabchi

Open publisher page 6 citations

Abstract

The administration of aminoglutethimide (AG) to rats and dogs significantly increased activity of phenylethanolamine-Nmethyl transferase in the adrenal. This stimulation occurred in spite of decreased adrenal and plasma corticosteroid levels. A significant stimulation was also noted in hypophysectomized rats treated with AG as well as in rats treated with large doses of dexamethasone. These findings suggest that the stimulatory effect of AG on PNMT is not mediated through the pituitary adrenal cortical axis. The increase in activity was noted as early as 24 hr after AG administration. No evidence of diurnal variation in this enzyme was demonstrated in rats. (Endocrinology88: 384, 1971)

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What this paper is about

The administration of aminoglutethimide (AG) to rats and dogs significantly increased activity of phenylethanolamine-Nmethyl transferase in the adrenal. This stimulation occurred in spite of decreased adrenal and plasma corticosteroid levels. A significant stimulation was also noted in hypophysectomized rats treated with AG as well as in rats treated with large doses of dexamethasone. These findings suggest that the stimulatory effect of AG on PNMT is not mediated through the pituitary adrenal cortical axis. The increase in activity was noted as early as 24 hr after AG administration. No evidence of diurnal variation in this enzyme was demonstrated in rats. (Endocrinology88: 384, 1971)

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OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The administration of aminoglutethimide (AG) to rats and dogs significantly increased activity of phenylethanolamine-Nmethyl transferase in the adrenal. This stimulation occurred in spite of decreased adrenal and plasma corticosteroid levels. A significant stimulation was also noted in hypophysectomized rats treated with AG as well as in rats treated with large doses of dexamethasone. These findings suggest that the stimulatory effect of AG on PNMT is not mediated through the pituitary adrenal cortical axis. The increase in activity was noted as early as 24 hr after AG administration. No evidence of diurnal variation in this enzyme was demonstrated in rats. (Endocrinology88: 384, 1971)

Key concepts: Aminoglutethimide, Phenylethanolamine, Internal medicine, Endocrinology, Stimulation, Dexamethasone, Transferase, Phenylethanolamine N-methyltransferase

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Stimulatory Effect of Aminoglutethimide on Phenylethanolamine-N-methyl Transferase (PNMT)1 — Research Paper | ScholarLens