Calcium Pyrophosphate Dihydrate Crystal Deposition Disease: Nomenclature and Diagnostic Criteria

Editorials1 August 1977Calcium Pyrophosphate Dihydrate Crystal Deposition Disease: Nomenclature and Diagnostic CriteriaDANIEL J. MCCARTY, M.D.DANIEL J. MCCARTY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-2-240 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe variety of names suggested for the condition associated with deposits of calcium pyrophosphate dihydrate crystals is exceeded only by the variations of its clinical presentation. "Articular chondrocalcinosis" was used by Zitňan and Sitaj to designate the highly characteristic articular radiodensities used by them as the definitive diagnostic feature (1). "Pseudogout" was first used by me in these pages 15 years ago because we had discovered microcrystals of calcium pyrophosphate dihydrate in the leukocytes of fluid from inflamed joints (2). These seemed analogous to the sodium urate crystals associated with true gout that we had described previously.Both the diagnosis...References1. ZITŇAN D and SITAJ S: Chondrocalcinosis polyarticularis (familiaris). Cesk Rentgenol 14:27-34, 1960 MedlineGoogle Scholar2. MCCARTY D, KOHN N, and FAIRES J: The significance of calcium phosphate crystals in the synovial fluid of arthritic patients: "the pseudogout syndrome." I. Clinical aspects. Ann Intern Med 56:711-737, 1962 LinkGoogle Scholar3. MCCARTY D, HOGAN J, and GATTER R: Studies on pathological calcifications in human cartilage. I. Prevalence and types of crystal deposits in the menisci of two hundred fifteen cadavera. J Bone Joint Surg [Am] 48:309-325, 1966 CrossrefMedlineGoogle Scholar4. ZITŇAN D SITAJ S : Natural course of articular chondrocalcinosis. Arthritis Rheum 19:363-390, 1976 CrossrefMedlineGoogle Scholar5. SILCOX D and MCCARTY D: Elevated inorganic pyrophosphate concentrations in synovial fluids in osteoarthritis and pseudogout. J Lab Clin Med 83:518-531, 1974 MedlineGoogle Scholar6. HOWELL D, MUNIZ O, and PITA J: Extrusion of pyrophosphate into extracellular media by osteoarthritis cartilage incubates. J Clin Invest 56:1473-1480, 1975 CrossrefMedlineGoogle Scholar7. MENKES C, SIMAS F, and CHOURAKI L: Les arthropathies destructices de la chondrocalcinose. Rev Rhum 40:115-123, 1973 MedlineGoogle Scholar8. JACOBELLI S, MCCARTY D, and SILCOX D: Calcium pyrophosphate dihydrate crystal deposition in neuropathic joints. Four cases of polyarticular involvement. Ann Intern Med 79:340-347, 1973 LinkGoogle Scholar9. RESNICK D, NIWAYAMA G, and GOERGEN T: Clinical, radiographic, and pathologic abnormalities in calcium pyrophosphate dihydrate (CPPD) deposition disease; pseudogout. Radiology 122:1-15, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL J. MCCARTY, M.D.Affiliations: Department of Medicine The Medical College of Wisconsin Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImaging Features of Calcium Pyrophosphate Deposition Disease: Consensus Definitions From an International Multidisciplinary Working GroupReliability and Diagnostic Accuracy of Radiography for the Diagnosis of Calcium Pyrophosphate Deposition: Performance of the Novel Definitions Developed by an International Multidisciplinary Working GroupWhich are the most frequently involved peripheral joints in calcium pyrophosphate crystal deposition at imaging? A systematic literature review and meta-analysis by the OMERACT ultrasound – CPPD subgroupIdentifying Potential Classification Criteria for Calcium Pyrophosphate Deposition Disease: Item Generation and Item ReductionHigh prevalence of chondrocalcinosis and frequent comorbidity with calcium pyrophosphate deposition disease in patients with seronegative rheumatoid arthritisReview: Outcome measures in calcium pyrophosphate depositionAccuracy of synovial fluid analysis compared to histology for the identification of calcium pyrophosphate crystals: an ancillary study of the OMERACT US Working Group - CPPD subgroupThe diagnostic value of conventional radiography and musculoskeletal ultrasonography in calcium pyrophosphate deposition disease: a systematic literature review and meta-analysisSonographic assessment of calcium pyrophosphate deposition disease at wrist. A focus on the dorsal scapho-lunate ligamentAcute Calcium Pyrophosphate Crystal Arthritis Flare Rate and Risk Factors for RecurrenceBone status and aortic calcifications in chondrocalcinosis patientsCalcium pyrophosphate crystal deposition disease as a risk factor for cardiovascular diseasesHip Involvement in Patients With Calcium Pyrophosphate Deposition Disease: Potential and Limits of Musculoskeletal UltrasoundIssues in CPPD Nomenclature and ClassificationReview: Unmet Needs and the Path Forward in Joint Disease Associated With Calcium Pyrophosphate Crystal DepositionPseudogout among Patients Fulfilling a Billing Code Algorithm for Calcium Pyrophosphate Deposition DiseaseSynovial Fluid Findings and Demographic Analysis of Patients With Coexistent Intra-articular Monosodium Urate and Calcium Pyrophosphate CrystalsDifferences in Acute Phase Reactants between Gout and PseudogoutPseudogout of the First Metatarsophalangeal Joint Associated with Hallux ValgusCERVICAL TUMORAL CALCIUM PYROPHOSPHATE DIHYDRATE DEPOSITION DISEASE 28 YEARS AFTER SUBOCCIPITAL CRANIOTOMYMethotrexate as an alternative therapy for chronic calcium pyrophosphate deposition disease: An exploratory analysisChondrocalcinosis of the WristCalcium Crystal Deposition in the Ligamentum Flavum of the Lumbar Spine: Role of Sex Hormones and Transforming Growth Factor-.BETA.The role of calcium deposition in the ligamentum flavum causing a cauda equina syndrome and lumbar radiculopathyArthroscopy and chondrocalcinosisChondrocalcinosis and Other CalcificationsCalcium pyrophosphate dihydrate crystal deposition disease in the cervical ligamentum flavumInteraction of polymorphonuclear leukocytes with calcium pyrophosphate dihydrate crystals deposited in chondrocalcinosis cartilageGelenke, Sehnen und Sehnengleitgewebe, Bursen, FaszienGelenkeCalcium pyrophosphate dihydrate deposits in the cervical ligamenta flava causing myeloradiculopathyDisappearance of chondrocalcinosis following reflex sympathetic dystrophy syndromePhysiology of Articular CartilageExperimental modelsCervical radiculomyelopathy caused by deposition of calcium pyrophosphate dihydrate crystals in the ligamenta flava 1 August 1977Volume 87, Issue 2Page: 240-242KeywordsCalciumGoutUric acid ePublished: 1 December 2008 Issue Published: 1 August 1977 PDF downloadLoading ...