2008•Cytogenetics and Cell GeneticsRequires access

3-Aminobenzamide-induced sister chromatid exchanges are dependent on incorporated bromodeoxyuridine in DNA

T.S.B. Zwanenburg, A.T. Natarajan

Abstract

Data are presented establishing a direct correlation between 3-aminobenzamide-induced sister chromatid exchange (SCE) frequency and the level of bromodeoxyuridine (BrdU) incorporated into DNA. In addition, it is shown that most of the SCEs are induced in the second cell cycle, in which BrdU-containing DNA is used as the template for replication.

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Key concepts: Sister chromatids, Sister chromatid exchange, Bromodeoxyuridine, Biology, DNA, DNA replication, Chromatid, Genetics