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2013•Pediatric RheumatologyOpen access

PW01-029 – Relationship between apoptotic alterations and inflammation in familial Mediterranean fever

Gohar Mkrtchyan, Anna S. Boyajyan

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Abstract

A number of studies indicated that alterations of apoptosis and its regulation together with upregulated inflammatory response are involved in pathogenesis of familial Mediterranean fever (FMF). However, molecular and cellular mechanisms responsible for abnormalities in apoptosis and their relationship with autoinflammatory responses in FMF are not clear.

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What this paper is about

A number of studies indicated that alterations of apoptosis and its regulation together with upregulated inflammatory response are involved in pathogenesis of familial Mediterranean fever (FMF). However, molecular and cellular mechanisms responsible for abnormalities in apoptosis and their relationship with autoinflammatory responses in FMF are not clear.

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Available abstract

A number of studies indicated that alterations of apoptosis and its regulation together with upregulated inflammatory response are involved in pathogenesis of familial Mediterranean fever (FMF). However, molecular and cellular mechanisms responsible for abnormalities in apoptosis and their relationship with autoinflammatory responses in FMF are not clear.

Key concepts: Familial Mediterranean fever, Medicine, Inflammation, Rheumatology, Pyrin domain, Apoptosis, Internal medicine, Immunology

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