2007•Drug Metabolism and PharmacokineticsRequires access

Characterization of Hepatobiliary Organic Anion Transporters in Long-Evans Cinnamon Rats

Makoto Chiba, Shirou Itagaki, Masaki Kobayashi, Takeshi Hirano, Ken Iseki

Abstract

The liver plays important roles in the detoxification of xenobiotics. Hepatobiliary transporters contribute to hepatic uptake and efflux processes of xenobiotecs. Expressions of these transporters may be modulated under the condition of hepatic failure. Long-Evans Cinnamon (LEC) rats provide a pertinent model for basic and clinical studies on hepatitis. However, only a few reports describing the properties of hepatobiliary transporters in LEC rats have appeared in the literature. We investigated the expression levels of hepatobiliary transporters in LEC rats by real-time RT-PCR. We found that hepatic expressions of three sinusoidal organic anion transporters, Ntcp, Oatp1a1 and Oatp1a4, were decreased in LEC rats. However, no significant difference of the expressions of Mrp2 and Bsep, organic anion transporters located on canalicular membrane, were found between Wistar rats and LEC rats.

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Key concepts: Multidrug resistance-associated protein 2, Organic anion transporter 1, Transporter, Organic anion-transporting polypeptide, Efflux, Chemistry, Detoxification (alternative medicine), Internal medicine