2013Journal of Macromolecular Science Part BRequires access

Synthesis and Antibacterial Activities of Quaternary Ammonium Salt of Gelatin

Qingwei Jiang, Jing Xu, Tianduo Li, Congde Qiao, Yulong Li

Open publisher page 33 citations

Abstract

Cationic proteins with tunable chemical and physical properties were prepared from 2,3-epoxypropyl trimethyl ammonium chloride (EPTAC) and gelatin. Measurement of grafting density indicated that the molar ratio of EPTAC/amine groups (NH2) in the gelatin chains played a key role in determining the compound's structure. Fourier transform infrared (FTIR) and 13C NMR results showed that the –NH2 functional groups of gelatin were totally consumed when the molar ratio of EPTAC/NH2 was increased to 2.5:1. Hydroxyl (‒OH) functional groups of gelatin were also depleted upon further increasing the molar ratio of EPTAC/NH2. Antibacterial activity and thermal properties of the product polymers changed with the modification of the polymers’ structure.

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Cationic proteins with tunable chemical and physical properties were prepared from 2,3-epoxypropyl trimethyl ammonium chloride (EPTAC) and gelatin. Measurement of grafting density indicated that the molar ratio of EPTAC/amine groups (NH2) in the gelatin chains played a key role in determining the compound's structure. Fourier transform infrared (FTIR) and 13C NMR results showed that the –NH2 functional groups of gelatin were totally consumed when the molar ratio of EPTAC/NH2 was increased to 2.5:1. Hydroxyl (‒OH) functional groups of gelatin were also depleted upon further increasing the molar ratio of EPTAC/NH2. Antibacterial activity and thermal properties of the product polymers changed with the modification of the polymers’ structure.

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Available abstract

Cationic proteins with tunable chemical and physical properties were prepared from 2,3-epoxypropyl trimethyl ammonium chloride (EPTAC) and gelatin. Measurement of grafting density indicated that the molar ratio of EPTAC/amine groups (NH2) in the gelatin chains played a key role in determining the compound's structure. Fourier transform infrared (FTIR) and 13C NMR results showed that the –NH2 functional groups of gelatin were totally consumed when the molar ratio of EPTAC/NH2 was increased to 2.5:1. Hydroxyl (‒OH) functional groups of gelatin were also depleted upon further increasing the molar ratio of EPTAC/NH2. Antibacterial activity and thermal properties of the product polymers changed with the modification of the polymers’ structure.

Key concepts: Gelatin, Cationic polymerization, Fourier transform infrared spectroscopy, Ammonium, Salt (chemistry), Antibacterial activity, Chemistry, Amine gas treating

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