ScholarLens Back to search
1985•European Journal of EndocrinologyRequires access

Plasma growth hormone and thyroxine levels in the chronically catheterised pig foetus and the effect of thyrotrophin releasing hormone

Alastair A. Macdonald, G.S.G. Spencer, K.G. Hallett

Open publisher page 9 citations

Abstract

The circulating levels of growth hormone and thyroxine during the last 2 weeks of gestation, and the effect of thyrotrophin releasing hormone on their secretion, has been examined in 13 chronically catheterised pig foetuses. Porcine growth hormone, measured by homologous radioimmunoassay, in the foetal plasma was found to average 83.5 +/- 10.3 ng/ml, while thyroxine levels were 92.9 +/- 4.1 nmol/l. There was no change in thyroxine or growth hormone levels with gestational age. Injection of 5 micrograms TRH produced a marked increase in plasma growth hormone levels (+194 +/- 51 ng/ml) but no change in thyroxine was observed. Injection of saline and subsequent blood sampling had no effect on the levels of either growth hormone or thyroxine.

About this research paper

What this paper is about

The circulating levels of growth hormone and thyroxine during the last 2 weeks of gestation, and the effect of thyrotrophin releasing hormone on their secretion, has been examined in 13 chronically catheterised pig foetuses. Porcine growth hormone, measured by homologous radioimmunoassay, in the foetal plasma was found to average 83.5 +/- 10.3 ng/ml, while thyroxine levels were 92.9 +/- 4.1 nmol/l. There was no change in thyroxine or growth hormone levels with gestational age. Injection of 5 micrograms TRH produced a marked increase in plasma growth hormone levels (+194 +/- 51 ng/ml) but no change in thyroxine was observed. Injection of saline and subsequent blood sampling had no effect on the levels of either growth hormone or thyroxine.

Why it matters

OpenAlex reports 9 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The circulating levels of growth hormone and thyroxine during the last 2 weeks of gestation, and the effect of thyrotrophin releasing hormone on their secretion, has been examined in 13 chronically catheterised pig foetuses. Porcine growth hormone, measured by homologous radioimmunoassay, in the foetal plasma was found to average 83.5 +/- 10.3 ng/ml, while thyroxine levels were 92.9 +/- 4.1 nmol/l. There was no change in thyroxine or growth hormone levels with gestational age. Injection of 5 micrograms TRH produced a marked increase in plasma growth hormone levels (+194 +/- 51 ng/ml) but no change in thyroxine was observed. Injection of saline and subsequent blood sampling had no effect on the levels of either growth hormone or thyroxine.

Key concepts: Endocrinology, Internal medicine, Radioimmunoassay, Hormone, Gestation, Growth hormone, Fetus, Saline

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Plasma growth hormone and thyroxine levels in the chronically catheterised pig foetus and the effect of thyrotrophin releasing hormone — Research Paper | ScholarLens