1987•Nucleosides and NucleotidesRequires access

Synthesis Of Oligodeoxyribonucleotides Containing an Aliphatic Amino Linker Arm at Selected Adenine Bases and Derivatization with Biotin

Jean‐Paul Roduit, Jeffrey P. Shaw, Angelika Chollet, André Chollet

Abstract

The chemical synthesis and characterization of oligodeoxyribonucleotides with a “linker arm” attached to the 8-position of some adenine bases are presented. Derivatizatlon with biotin is described and evaluation of these modified DNA fragments as nonradioactive hybridization probes is briefly discussed.

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Key concepts: Linker, Biotin, Derivatization, Chemistry, Combinatorial chemistry, DNA, Stereochemistry, Biochemistry