1987•Proceedings of the National Academy of SciencesOpen access
Genetic linkage map of human chromosome 7 with 63 DNA markers.
David Barker, P Green, Robert G. Knowlton, James W. Schumm, Eric S. Lander, Arnold Oliphant, H.F. Willard, Gita Akots, Valerie A. Brown, Thomas C. Gravius
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Abstract
High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have constructed a genetic map of chromosome 7 with 63 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed multilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.