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[Biosynthesis of the peptide alkaloids of Claviceps purpurea].

D. Gröger, Dieter Erge

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Abstract

Using a strain of Claviceps purpurea which produces under submerged conditions chanoclavine, ergometrine and mainly ergotoxine the biosynthesis of ergoline derivatives has been studied. DL-Tryptophan- (ring-2-¹⁴C) is specifically incorporated into the lysergic acid moiety of ergotoxine· alkaloids. L-Proline-U-¹⁴C serves as a precursor of the proline-part of the peptid-chain of ergotoxine.

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What this paper is about

Using a strain of Claviceps purpurea which produces under submerged conditions chanoclavine, ergometrine and mainly ergotoxine the biosynthesis of ergoline derivatives has been studied. DL-Tryptophan- (ring-2-¹⁴C) is specifically incorporated into the lysergic acid moiety of ergotoxine· alkaloids. L-Proline-U-¹⁴C serves as a precursor of the proline-part of the peptid-chain of ergotoxine.

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Available abstract

Using a strain of Claviceps purpurea which produces under submerged conditions chanoclavine, ergometrine and mainly ergotoxine the biosynthesis of ergoline derivatives has been studied. DL-Tryptophan- (ring-2-¹⁴C) is specifically incorporated into the lysergic acid moiety of ergotoxine· alkaloids. L-Proline-U-¹⁴C serves as a precursor of the proline-part of the peptid-chain of ergotoxine.

Key concepts: Claviceps purpurea, Lysergic acid, Biosynthesis, Ergometrine, Proline, Moiety, Chemistry, Stereochemistry

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