2005•Analytical LettersRequires access

Solid Phase Extraction of Olanzapine with Reverse Phase Sorbents Prior to UV and HPLC Analysis

Anna Jasińska, Barbara Starczewska, Monika Polkowska, Helena Puzanowska‐Tarasiewicz

Abstract

A solid‐phase extraction (SPE) method for the sample clean‐up followed by a UV and reversed‐phase high performance liquid chromatography (HPLC) procedure for the assay of olanzapine (OLA) is reported. SPE was carried out using the octadecyl (C18), cyclohexyl (C6H11) columns, which belong to the reverse phase sorbents and the SDB‐1 column, define as polymeric sorbent. The spiked albumin samples were used to examine the recoveries of olanzapine from the investigated sorbent materials. The volume of albumin samples was 500 µl. The best extraction recoveries were performed with C18 cartridges and these varied between 99.0–100.5% and 98.5–104.0% prior to our UV and literature HPLC analysis, respectively.

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Key concepts: Chemistry, Chromatography, Solid phase extraction, Sorbent, High-performance liquid chromatography, Extraction (chemistry), Cartridge, Sample preparation