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1962•Canadian Journal of Biochemistry and PhysiologyRequires access

EXCRETION OF 4-AMINO-5-IMIDAZOLECARBOXAMIDE AND CREATINE:CREATININE RATIOS IN HUMAN AND MOUSE MUSCULAR DYSTROPHY

Edith G. McGeer, P. L. McGeer, James R. Miller, Douglas Derry, C. Nichol

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Abstract

Excretion of creatine, creatinine, and 4-amino-5-imidazolecarboxamide (AIC) was studied in genetically determined muscular dystrophy in the human and mouse. The AIC excretion was normal in both affected humans and mice as compared with groups of comparably aged controls. The creatine-to-creatinine ratio for human muscular dystrophics was more than four times as great as for their unaffected siblings. Both normal and dystrophic mice showed a "creatinuria" as compared to humans. The creatine-to-creatinine ratio for dystrophic mice was significantly higher than the controls, but the difference was apparent only in the first 2 months of life.

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What this paper is about

Excretion of creatine, creatinine, and 4-amino-5-imidazolecarboxamide (AIC) was studied in genetically determined muscular dystrophy in the human and mouse. The AIC excretion was normal in both affected humans and mice as compared with groups of comparably aged controls. The creatine-to-creatinine ratio for human muscular dystrophics was more than four times as great as for their unaffected siblings. Both normal and dystrophic mice showed a "creatinuria" as compared to humans. The creatine-to-creatinine ratio for dystrophic mice was significantly higher than the controls, but the difference was apparent only in the first 2 months of life.

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Available abstract

Excretion of creatine, creatinine, and 4-amino-5-imidazolecarboxamide (AIC) was studied in genetically determined muscular dystrophy in the human and mouse. The AIC excretion was normal in both affected humans and mice as compared with groups of comparably aged controls. The creatine-to-creatinine ratio for human muscular dystrophics was more than four times as great as for their unaffected siblings. Both normal and dystrophic mice showed a "creatinuria" as compared to humans. The creatine-to-creatinine ratio for dystrophic mice was significantly higher than the controls, but the difference was apparent only in the first 2 months of life.

Key concepts: Creatine, Creatinine, Muscular dystrophy, Endocrinology, Internal medicine, Excretion, Chemistry, Medicine

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EXCRETION OF 4-AMINO-5-IMIDAZOLECARBOXAMIDE AND CREATINE:CREATININE RATIOS IN HUMAN AND MOUSE MUSCULAR DYSTROPHY — Research Paper | ScholarLens