A simple model for teaching indirect ophthalmoscopy

reported.8 In one of these reported patients, who were positive for both ANA and HLA-B27, hypopyon had been described in association with the recurrent episodes of AAU that developed during adulthood.The hypopyon described in that case occurred in the context of HLA-B27 associated AAU in an adult, distinct from and temporally following, clinical features of childhood ANA positive CAU. 8 In contrast, our reported patient developed recurrent spontaneous hypopyon (at the age of 5) in the context of the typical, insidious CAU without any clinical features of HLA-B27 associated AAU.It remains unclear whether the presence of HLA-B27 antigen in our patient is a coincidence or whether it is of pathogenic significance.HLA-B27 antigen may represent a risk factor for the development of hypopyon in anterior uveitis, even in those that do not display the typical phenotype of HLA-B27 associated AAU.It would be of interest to follow the clinical course of our patient into her adulthood to determine whether she later develops ocular or systemic features of HLA-B27 associated AAU.Further studies of a cohort of ANA and HLA-B27 positive children with uveitis are indicated to investigate their clinical phenotype and the potential interaction between ANA and HLA-B27.