2002•ChemBioChemRequires access
Synthesis and Characterisation of Acyl Carrier Protein Bound Polyketide Analogues
Christopher J. Arthur, Russell J. Cox, John Crosby, Mujiber M. Rahman, Thomas J. Simpson, Florilène Soulas, Roberto Spogli, Anna E. Szafranska, James Westcott, Christopher J. Winfield
Open publisher page 18 citations
Abstract
β-oxoacyl thiolesters of N-acetylcysteamine (SNACs, see structure) were synthesised and shown to be substrates for the self-acylation reaction of the Type II actinorhodin polyketide synthase holo acyl carrier protein (ACP). The preparation of ACPs bearing analogues of polyketide biosynthesis intermediates is described.