1995•Phytotherapy ResearchRequires access

Antihepatotoxic Effects of chlorogenic acid from Anthocephalus cadamba

Aruna Kapil, Indu Bala KOUL, Om Parkash Suri

Abstract

Abstract In the present study, chlorogenic acid (CGA) isolated from Anthocephalus cadamba was screened for hepatoprotective activity by in vitro and in vivo assay methods using carbon tetrachloride (CCl4) as a model of liver injury. Intraperitoneal administration of CGA to mice at a dose of 100 mg/kg body weight for 8 days caused significant reversal in lipid peroxidation, enzymatic leakage, cytochrome P450 (Cyt P450) inactivation and produced enhancement of cellular antioxidant defence in CCl4‐intoxicated mice, revealing that the antioxidative action of CGA is responsible for its liver protective activity. CGA exhibited a better therapeutic protective action than silymarin (SM), in CCl4‐administered mice.

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Key concepts: Carbon tetrachloride, Chlorogenic acid, Lipid peroxidation, Pharmacology, Antioxidant, In vivo, Chemistry, Liver injury