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Studies on the Aspartic Acid "Sparing Effect" on the Nutritional Requirement of L-Asparagine for Tumors in Vitro

M. K. Patterson, Gerald R. Orr, Eugene Conway

Abstract

The L-aspartic acid sparing effect of the nutritional requirement for L-asparagine for the Jensen sarcoma and the Walker 256 carcinoma was reinvestigated. The effect was found only when the aspartic acid contained L-asparagine as a contaminant. Studies on the induction of asparagine synthetase by high concentrations of aspartic acid gave negative results.

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Key concepts: Aspartic acid, Asparagine, In vitro, Biochemistry, Chemistry, Asparagine synthetase, Amino acid, Biology