1991•Antimicrobial Agents and ChemotherapyOpen access

Uptake of sparfloxacin and norfloxacin by clinical isolates of Staphylococcus aureus

Shuhei Yoshida, Tsuyoshi Kojima, Manabu Inoue, S Mitsuhashi

Abstract

The amount of sparfloxacin uptake was higher than that of norfloxacin uptake in Staphylococcus aureus. Moreover, energy-dependent reduction in quinolone uptake, probably due to active efflux of the quinolone, was observed. The reduction in quinolone uptake appeared to be associated with quinolone resistance in S. aureus.

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Available abstract

Key concepts: Sparfloxacin, Norfloxacin, Quinolone, Efflux, Staphylococcus aureus, Microbiology, Chemistry, Antibacterial agent