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1997•Journal of the Chemical Society Perkin Transactions 1Requires access

Synthesis of a cis-conformationally restricted peptide bond isostere and its application to the inhibition of the HIV-1 protease

Andrew D. Abell, Glenn J. Foulds

Open publisher page 72 citations

Abstract

A synthesis of a new, tetrazole-based, cis-constrained hydroxyethylamine peptide bond isostere is reported. This has been used to produce a new class of HIV-1 protease inhibitor.

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What this paper is about

A synthesis of a new, tetrazole-based, cis-constrained hydroxyethylamine peptide bond isostere is reported. This has been used to produce a new class of HIV-1 protease inhibitor.

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OpenAlex reports 72 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A synthesis of a new, tetrazole-based, cis-constrained hydroxyethylamine peptide bond isostere is reported. This has been used to produce a new class of HIV-1 protease inhibitor.

Key concepts: Isostere, HIV-1 protease, Chemistry, Protease, Peptide, Stereochemistry, Human immunodeficiency virus (HIV), Peptide bond

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