NON-SURGICAL TREATMENT OF CIRRHOSIS OF THE LIVER

active under bromid perfusion, but our series of experiments is nol complete enough to state whether or not there is local change in sensitiveness to vagus control.EXPERIMENTS ON THE ISOLATED MAMMALIAN HEART From the therapeutic point of view, read ions of the warm-blooded hear! to the bromids is of more interest perhaps than the reactions of the cold-blooded heart.We have made a number of tests by a method which depends on coronary perfusion. [solated cai hearts were maintained under a perfusion oí :l parts chlorid- Ringer's solution, and 1 pari cat hlood.A carefully balanced bromid-Ringer's diluted wilh Ihe same amount of cal blood was used for testing the bromids.The warm-blooded heart is inure sensitive lo the bro- mids than is the cold-blooded hear!.Our tesis have nol heen absolutely constant.Oui oí thirteen experiments three showed primary acceleration of rale, which is generally obtained in the cold-blooded heart.The remaining experiments show primary depression in rale.In all experiments Hiere was a depression of amplitude, [f Ihe bromid perfusion was for only a relatively short period then there followed a gradual but slow recovery in both rate and amplitude on renewing Ihe normal lunger's and blood.In long bromid perfusions arhyth- niia often sets in which may be removed wilh chloridllingcr's blood. DISCUSSION OF RESULTSIn summarizing these results one mus!admit that the inorganic bromids are relatively indifferent to such organs as the heart of the cold-blooded vertebrates.On the hearts oí warni-blooded animals the bromids are in the long run sharply depressant whether they he meas- ured by rale or by amplitude.If the bromids are com- bined wilh bases in strictly physiologically balanced solutions they are relatively non-toxic, especially to car- diac muscle.On the other hand, if the sails are used without reference to the physiologie balance oí bases it often happens that react ions oí Ihe heart are relatively misleading, owing not to the primary toxicity of the bromid anion hut to the influence oí (lie base or cation.This is particularly true of potassium bromid.Looking over the literature we cannot escape the conclusion that many of the so-called bromid therapeutic effects are distinctly chargeable to the base with which Ihe bromid has been combined.Correlation between Complexion and Resistance to Auto- Intoxication.-1should like to call attention to the extraor-