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The Effect of Exogenous DNA and of Other Humoral Factors on the Spleen-nodule Count after Whole-body Irradiation

V. Jurášková, V. Drášil

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Abstract

SummaryUsing the spleen colony method we studied the effect of exogenous DNA and several other substances on the recovery of haematopoietic tissue in the spleens of irradiated mice. The greatest increase in the number of endogenous colonies in the spleen of irradiated animals was found when a single injection of isologous or homologous DNA was given shortly after exposure. Heterologous DNA had only a small effect. Of other substances tested heterologous milk had the greatest effect on the mean number of colonies. These results are briefly discussed.

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SummaryUsing the spleen colony method we studied the effect of exogenous DNA and several other substances on the recovery of haematopoietic tissue in the spleens of irradiated mice. The greatest increase in the number of endogenous colonies in the spleen of irradiated animals was found when a single injection of isologous or homologous DNA was given shortly after exposure. Heterologous DNA had only a small effect. Of other substances tested heterologous milk had the greatest effect on the mean number of colonies. These results are briefly discussed.

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SummaryUsing the spleen colony method we studied the effect of exogenous DNA and several other substances on the recovery of haematopoietic tissue in the spleens of irradiated mice. The greatest increase in the number of endogenous colonies in the spleen of irradiated animals was found when a single injection of isologous or homologous DNA was given shortly after exposure. Heterologous DNA had only a small effect. Of other substances tested heterologous milk had the greatest effect on the mean number of colonies. These results are briefly discussed.

Key concepts: Heterologous, Spleen, DNA, Biology, Haematopoiesis, Homologous chromosome, Endogeny, Irradiation

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