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1969•EndocrinologyRequires access

Effects of Estrogens on Plasma Angiotensinogen and Renin Activity in Nephrectomized Rats

Alberto Nasjletti, Masato Matsunaga, Georges M. C. Masson

Open publisher page 24 citations

Abstract

Administration of stilbestrol to bilaterally nephrectomized rats causes an increase in plasma angiotensinogen concentration which is superimposed on that elicited by nephrectomy and an increase in plasma renin activity. These changes are present in females, normal or hysterectomized, and in males. SemipurifiedSemipurified angiotensinogen prepared from such plasma contains minute amounts of a renin-like material which upon incubation releases a pressor substance having the characteristics of angiotensin. The origin of this enzyme is not known. (Endocrinology85: 967, 1969)

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Administration of stilbestrol to bilaterally nephrectomized rats causes an increase in plasma angiotensinogen concentration which is superimposed on that elicited by nephrectomy and an increase in plasma renin activity. These changes are present in females, normal or hysterectomized, and in males. SemipurifiedSemipurified angiotensinogen prepared from such plasma contains minute amounts of a renin-like material which upon incubation releases a pressor substance having the characteristics of angiotensin. The origin of this enzyme is not known. (Endocrinology85: 967, 1969)

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OpenAlex reports 24 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Administration of stilbestrol to bilaterally nephrectomized rats causes an increase in plasma angiotensinogen concentration which is superimposed on that elicited by nephrectomy and an increase in plasma renin activity. These changes are present in females, normal or hysterectomized, and in males. SemipurifiedSemipurified angiotensinogen prepared from such plasma contains minute amounts of a renin-like material which upon incubation releases a pressor substance having the characteristics of angiotensin. The origin of this enzyme is not known. (Endocrinology85: 967, 1969)

Key concepts: Endocrinology, Internal medicine, Stilbestrol, Renin–angiotensin system, Plasma renin activity, Nephrectomy, Chemistry, Plasma levels

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Effects of Estrogens on Plasma Angiotensinogen and Renin Activity in Nephrectomized Rats — Research Paper | ScholarLens