1991•Current Opinion in NeurobiologyOpen access

Sodium-dependent neurotransmitter reuptake systems

Susan Amara, Tadeusz Pacholczyk

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Abstract

The recent cloning of the gamma-aminobutyric acid and norepinephrine Na(+)-dependent neurotransmitter transporters has led to new approaches for understanding the structure and function of these important synaptic proteins and provides a conceptual model in which to consider recent advances in the physiology, pharmacology and biochemistry of this gene family.

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What this paper is about

The recent cloning of the gamma-aminobutyric acid and norepinephrine Na(+)-dependent neurotransmitter transporters has led to new approaches for understanding the structure and function of these important synaptic proteins and provides a conceptual model in which to consider recent advances in the physiology, pharmacology and biochemistry of this gene family.

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Available abstract

The recent cloning of the gamma-aminobutyric acid and norepinephrine Na(+)-dependent neurotransmitter transporters has led to new approaches for understanding the structure and function of these important synaptic proteins and provides a conceptual model in which to consider recent advances in the physiology, pharmacology and biochemistry of this gene family.

Key concepts: Neurotransmitter transporter, Reuptake, Neurotransmitter, Neurotransmitter systems, Reuptake inhibitor, Neuroscience, Norepinephrine, Transporter

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