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Suppression of Food and Water Intake after Intracerebroventricular Infusion of Morphine and Naloxone in Rabbits

Anna Maria Konecka, B Sadowski, Joanna Jaszczak, Izabela Panocka, Irmina Sroczyńska

Abstract

The effect of intracerebroventricular infusion of morphine and naloxone on food and water intake was investigated in rabbits. Morphine hydrochloride at a dose of 120, 10 and 5 micrograms produced statistically significant suppression of 24-h food and water intake. The same effect ensued after infusion of naloxone at dose of 120 and 10 micrograms. Postmorphine aphagia was accompanied by a rise in blood free fatty acids and normal glucose levels. No changes were seen after naloxone.

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Key concepts: Naloxone Hydrochloride, (+)-Naloxone, Morphine, Water intake, Medicine, Anesthesia, Food intake, Opioid