2014•World Journal of Biological ChemistryOpen access

Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase

Rajib Sengupta

Abstract

Ribonucleotide reductase (RNR), the rate-limiting enzyme in DNA synthesis, catalyzes reduction of the different ribonucleotides to their corresponding deoxyribonucleotides. The crucial role of RNR in DNA synthesis has made it an important target for the development of antiviral and anticancer drugs. Taking account of the recent developments in this field of research, this review focuses on the role of thioredoxin and glutaredoxin systems in the redox reactions of the RNR catalysis.

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Key concepts: Ribonucleotide reductase, Glutaredoxin, Deoxyribonucleotides, Thioredoxin, Thioredoxin reductase, Ribonucleotide, Biochemistry, Reductase