1984•British Journal of Clinical PharmacologyOpen access

Local anaesthetic effect of antiarrhythmic drugs and human sperm immobilization: mechanism and application of the interrelationship.

CY Hong, B.N. Chiang

Abstract

Sperm immobilizing activity of three class I antiarrhythmic drugs, quinidine, procainamide, mexiletine, one adrenoceptor blocking drug, labetalol and one calcium channel blocking drug, diltiazem was measured with a trans-membrane migration method. All these drugs immobilized human sperm. Local anaesthetic effect is the underlying mechanism for these drugs to inhibit sperm motility. Sperm immobilization could be a screening test for the local anaesthetic effect of antiarrhythmic drugs.

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Key concepts: Quinidine, Diltiazem, Mexiletine, Procainamide, Pharmacology, Sperm, Chemistry, Sperm motility