1998•Inorganic ChemistryRequires access

Oxovanadium(IV)-Promoted Peptide-Amide Deprotonation in Aqueous Solution

Tivadar Kiss, K. Petrohán, Péter Buglyó, Daniele Sanna, Giovanni Micera, João Costa Pessoa, Catarina Madeira

Abstract

The speciation and solution structural studies of the complexes formed in the aqueous solution of oxovanadium(IV) and 2-hydroxyhippuric acid (a pseudopeptide, SalGly) revealed that the metal ion-promoted deprotonation and coordination of the peptide-amide occurs at pH as low as 4 and the complex formed is the predominant species at physiological pH.

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Key concepts: Deprotonation, Chemistry, Amide, Aqueous solution, Peptide, Metal, Genetic algorithm, Ion