Cross-Resistance to Purine Analogs in Hairy Cell Leukemia

Letters1 February 1994Cross-Resistance to Purine Analogs in Hairy Cell LeukemiaEric H. Kraut, MDEric H. Kraut, MDThe Ohio State University; Columbus, OH 43210-1228Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-3-199402010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the article by Drs. Saven and Piro on the response of patients with hairy cell leukemia to 2-chlorodeoxyadenosine (2-CdA) after treatment with deoxycoformycin (dCF) failed [1]. In our experience, approximately 85% of patients respond completely to dCF [2]. Our results with 2-CdA after no response to dCF or another purine antimetabolite, fludarabine phosphate, are not as encouraging. We have treated three patients with 2-CdA for refractory hairy cell leukemia. Two had relapsed from dCF-induced complete remission and did not respond to retreatment. One patient was also given fludarabine phosphate before 2-CdA treatment. Neither ...References1. Saven A, Piro LD. Complete remissions in hairy cell leukemia with 2-chlorodeoxyadenosine after failure with 2′deoxycoformycin. Ann Intern Med. 1993; 119:278-83. Google Scholar2. Kraut EH, Bouroncle BA, Grever M. Pentostatin treatment of advanced hairy cell leukemia. J Clin Oncol. 1989; 7:168-72. Google Scholar3. Kraut EH, Chun H. Fludarabine phosphate in refractory hairy cell leukemia. Am J Hematol. 1991; 37:59-60. Google Scholar Author, Article, and Disclosure InformationAuthors: Eric H. Kraut, MDAffiliations: The Ohio State University; Columbus, OH 43210-1228 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTreatment Options for Hairy Cell LeukemiaLa leucémie à tricholeucocytes: approches thérapeutiques 1 February 1994Volume 120, Issue 3Page: 247-248KeywordsDeoxycoformycinDrug therapyInterferonsNucleosidesPatientsPhosphatesPurines ePublished: 15 August 2000 Issue Published: 1 February 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...