ScholarLens Back to search
1998•Current Opinion in GastroenterologyRequires access

Inflammatory mediators in inflammatory bowel disease

Iris Dotan, Daniel Rachmilewitz

Open publisher page 3 citations

Abstract

Research this year concentrated on defining the role of inflamatory mediators and their modulation in the treatment of inflammatory bowel disease and experimental colitis. Whereas leukotriene B4 blockade was found to have no effect on ulcerative colitis, blockade of thromboxane A2, the inducible nitric oxide synthase, and elimination of oxygen radicals seemed efficacious in animal models. Interest in nitric oxide and oxygen free radicals increased, demonstrating the deleterious effect these molecules have on intestinal inflammation.

About this research paper

What this paper is about

Research this year concentrated on defining the role of inflamatory mediators and their modulation in the treatment of inflammatory bowel disease and experimental colitis. Whereas leukotriene B4 blockade was found to have no effect on ulcerative colitis, blockade of thromboxane A2, the inducible nitric oxide synthase, and elimination of oxygen radicals seemed efficacious in animal models. Interest in nitric oxide and oxygen free radicals increased, demonstrating the deleterious effect these molecules have on intestinal inflammation.

Why it matters

OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Research this year concentrated on defining the role of inflamatory mediators and their modulation in the treatment of inflammatory bowel disease and experimental colitis. Whereas leukotriene B4 blockade was found to have no effect on ulcerative colitis, blockade of thromboxane A2, the inducible nitric oxide synthase, and elimination of oxygen radicals seemed efficacious in animal models. Interest in nitric oxide and oxygen free radicals increased, demonstrating the deleterious effect these molecules have on intestinal inflammation.

Key concepts: Inflammatory bowel disease, Nitric oxide, Ulcerative colitis, Blockade, Inflammation, Nitric oxide synthase, Leukotriene B4, Colitis

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Inflammatory mediators in inflammatory bowel disease — Research Paper | ScholarLens