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1968•Journal of the Chemical Society B Physical OrganicRequires access

Studies on benzimidazoles. Part IV. Nucleophilic displacement of N-substituted 2-halogenobenzimidazoles by thiophenol

Andrea Ricci, PIERO VIVARELLI

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Abstract

2-Halogenobenzimidazoles react with thiophenol as well as with benzenethiolate ion. The reaction also occurs in acidic medium. The effect on the reaction of structural modifications in the benzimidazole and in the thiophenol have been investigated. The general kinetic equation Rate =k1[B][ArS–]+k2[BH+][ArSH]+k3[BH+][ArS–] is proposed to explain the overall reaction.

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What this paper is about

2-Halogenobenzimidazoles react with thiophenol as well as with benzenethiolate ion. The reaction also occurs in acidic medium. The effect on the reaction of structural modifications in the benzimidazole and in the thiophenol have been investigated. The general kinetic equation Rate =k1[B][ArS–]+k2[BH+][ArSH]+k3[BH+][ArS–] is proposed to explain the overall reaction.

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Available abstract

2-Halogenobenzimidazoles react with thiophenol as well as with benzenethiolate ion. The reaction also occurs in acidic medium. The effect on the reaction of structural modifications in the benzimidazole and in the thiophenol have been investigated. The general kinetic equation Rate =k1[B][ArS–]+k2[BH+][ArSH]+k3[BH+][ArS–] is proposed to explain the overall reaction.

Key concepts: Thiophenol, Chemistry, Nucleophile, Benzimidazole, Nucleophilic substitution, Ion, Medicinal chemistry, Combinatorial chemistry

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Studies on benzimidazoles. Part IV. Nucleophilic displacement of N-substituted 2-halogenobenzimidazoles by thiophenol — Research Paper | ScholarLens