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2008•British Journal of NeurosurgeryRequires access

Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford

Erlick Pereira, Kalai Arasu Muthusamy, Nick de Pennington, Carole Joint, Tipu Z. Aziz

Open publisher page 79 citations

Abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here, we summarize our non-human primate and neuroimaging research of relevance to our surgical targeting of the PPN. We also describe our clinical experience of PPN DBS with greatest motor improvements achieved by stimulation at low frequencies.

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What this paper is about

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here, we summarize our non-human primate and neuroimaging research of relevance to our surgical targeting of the PPN. We also describe our clinical experience of PPN DBS with greatest motor improvements achieved by stimulation at low frequencies.

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OpenAlex reports 79 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here, we summarize our non-human primate and neuroimaging research of relevance to our surgical targeting of the PPN. We also describe our clinical experience of PPN DBS with greatest motor improvements achieved by stimulation at low frequencies.

Key concepts: Pedunculopontine nucleus, Deep brain stimulation, Medicine, Parkinson's disease, Neuroscience, Postural instability, Neuroimaging, Stimulation

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Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford — Research Paper | ScholarLens