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Thyrotropin and Propylthiouracil-Induced Stimulation of Thyroidal Creatine Phosphokinase and Lactic Dehydrogenase in the Rat

Frank A. Graig

Open publisher page 4 citations

Abstract

Creatine phosphokinase (CPK) and lactic dehydrogenase (LDH) activity was measured in thyroid and myocardial tissue of control, TSH-injected and propylthiouraciltreated rats. Exogenous TSH increased the per g activity and specific activity of both enzymes in the thyroid gland. Endogenous TSH stimulationstimulation similarly enhanced thyroidal CPK and LDH activity but had no effect on myocardial enzymes. Lack of change from ACTH but selective increase by TSH of thyroidal enzymes suggest another specific effect of TSH. The possible significance of these findings is discussed. (Endocrinology81: 708, 1967)

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What this paper is about

Creatine phosphokinase (CPK) and lactic dehydrogenase (LDH) activity was measured in thyroid and myocardial tissue of control, TSH-injected and propylthiouraciltreated rats. Exogenous TSH increased the per g activity and specific activity of both enzymes in the thyroid gland. Endogenous TSH stimulationstimulation similarly enhanced thyroidal CPK and LDH activity but had no effect on myocardial enzymes. Lack of change from ACTH but selective increase by TSH of thyroidal enzymes suggest another specific effect of TSH. The possible significance of these findings is discussed. (Endocrinology81: 708, 1967)

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Available abstract

Creatine phosphokinase (CPK) and lactic dehydrogenase (LDH) activity was measured in thyroid and myocardial tissue of control, TSH-injected and propylthiouraciltreated rats. Exogenous TSH increased the per g activity and specific activity of both enzymes in the thyroid gland. Endogenous TSH stimulationstimulation similarly enhanced thyroidal CPK and LDH activity but had no effect on myocardial enzymes. Lack of change from ACTH but selective increase by TSH of thyroidal enzymes suggest another specific effect of TSH. The possible significance of these findings is discussed. (Endocrinology81: 708, 1967)

Key concepts: Propylthiouracil, Internal medicine, Endocrinology, Creatine kinase, Thyroid, Lactic dehydrogenase, Stimulation, Enzyme

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