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1970•European Journal of EndocrinologyRequires access

HYPOTHALAMIC-PITUITARY-ADRENAL FUNCTION IN OBESITY AND THE CORTISOL SECRETION RATE FOLLOWING PROLONGED STARVATION

IVOR M. D. JACKSON, Joy I. Mowat

Open publisher page 12 citations

Abstract

ABSTRACT Evaluation of the hypothalamic-pituitary-adrenal axis was undertaken in obesity. Abnormality of diurnal rhythm of plasma cortisol, elevated cortisol secretion rate (CSR) and, to a lesser extent, excessive response to adrenal stimulation, were found in a proportion of cases. Adequate hypoglycaemia invariably produced a significant cortisol rise and 80% of cases responded to L.8 vasopressin at 5 units im. A significant fall in CSR, urinary 17-OHCS and 17-KS occurred with starvation. The significance of these findings in relation to Cushing's syndrome is discussed.

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ABSTRACT Evaluation of the hypothalamic-pituitary-adrenal axis was undertaken in obesity. Abnormality of diurnal rhythm of plasma cortisol, elevated cortisol secretion rate (CSR) and, to a lesser extent, excessive response to adrenal stimulation, were found in a proportion of cases. Adequate hypoglycaemia invariably produced a significant cortisol rise and 80% of cases responded to L.8 vasopressin at 5 units im. A significant fall in CSR, urinary 17-OHCS and 17-KS occurred with starvation. The significance of these findings in relation to Cushing's syndrome is discussed.

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Available abstract

ABSTRACT Evaluation of the hypothalamic-pituitary-adrenal axis was undertaken in obesity. Abnormality of diurnal rhythm of plasma cortisol, elevated cortisol secretion rate (CSR) and, to a lesser extent, excessive response to adrenal stimulation, were found in a proportion of cases. Adequate hypoglycaemia invariably produced a significant cortisol rise and 80% of cases responded to L.8 vasopressin at 5 units im. A significant fall in CSR, urinary 17-OHCS and 17-KS occurred with starvation. The significance of these findings in relation to Cushing's syndrome is discussed.

Key concepts: Endocrinology, Internal medicine, Starvation, Cortisol awakening response, Circadian rhythm, Medicine, Stimulation, Vasopressin

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