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2003•Chinese Journal of Cancer ResearchRequires access

Up-regulation of cyclooxygenase-2 gene expression correlates with tumor angiogenesis in human breast cancer

Zhi-jun Dai, Xi-Jing Wang, Xiaoxu Liu, Huafeng Kang, Jiahuan Jiang, Haitao Guan, Shu-Qun Zhang, Xue Xing-huan, Feng-jie Xue

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Abstract

Objective: To study the relationship between cyclooxygenase-2 (COX-2) expression and tumor angiogenesis in human breast cancer. Methods: Archival primary breast carcinomas (n=62), adjacent ductal carcinoma in situ (DCIS, n=13) and DCIS alone (n=5) were analyzed for COX-2 and VEGF expression by immunohistochemistry using specific monoclonal antibodies. Microvessel density (MVD) was also examined the using CD34 staining. Results: A significant correlation was found between COX-2 and VEGF expression ( P <0.01). Both COX-2 and VEGF were significantly correlated with MVD ( P <0.05) and P <0.01, respectively). COX-2 and VEGF genes were overexpressed in tumor specimens as compared with normal epithelia. Conclusion: COX-2 is related to tumor angiogenesis in breast cancer. It is likely that VEGF is one of the most important mediators of the COX-2 angiogenic pathway.

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What this paper is about

Objective: To study the relationship between cyclooxygenase-2 (COX-2) expression and tumor angiogenesis in human breast cancer. Methods: Archival primary breast carcinomas (n=62), adjacent ductal carcinoma in situ (DCIS, n=13) and DCIS alone (n=5) were analyzed for COX-2 and VEGF expression by immunohistochemistry using specific monoclonal antibodies. Microvessel density (MVD) was also examined the using CD34 staining. Results: A significant correlation was found between COX-2 and VEGF expression ( P <0.01). Both COX-2 and VEGF were significantly correlated with MVD ( P <0.05) and P <0.01, respectively). COX-2 and VEGF genes were overexpressed in tumor specimens as compared with normal epithelia. Conclusion: COX-2 is related to tumor angiogenesis in breast cancer. It is likely that VEGF is one of the most important mediators of the COX-2 angiogenic pathway.

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Available abstract

Objective: To study the relationship between cyclooxygenase-2 (COX-2) expression and tumor angiogenesis in human breast cancer. Methods: Archival primary breast carcinomas (n=62), adjacent ductal carcinoma in situ (DCIS, n=13) and DCIS alone (n=5) were analyzed for COX-2 and VEGF expression by immunohistochemistry using specific monoclonal antibodies. Microvessel density (MVD) was also examined the using CD34 staining. Results: A significant correlation was found between COX-2 and VEGF expression ( P <0.01). Both COX-2 and VEGF were significantly correlated with MVD ( P <0.05) and P <0.01, respectively). COX-2 and VEGF genes were overexpressed in tumor specimens as compared with normal epithelia. Conclusion: COX-2 is related to tumor angiogenesis in breast cancer. It is likely that VEGF is one of the most important mediators of the COX-2 angiogenic pathway.

Key concepts: Angiogenesis, Immunohistochemistry, CD34, Breast cancer, Cyclooxygenase, Medicine, Cancer, Pathology

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Up-regulation of cyclooxygenase-2 gene expression correlates with tumor angiogenesis in human breast cancer — Research Paper | ScholarLens