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2015•Organic LettersOpen access

Efficient Isocyanide-less Isocyanide-Based Multicomponent Reactions

Constantinos G. Neochoritis, Silvia Stotani, Bhupendra A. Mishra, Alexander S. S. Dömling

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Abstract

Isocyanides are the "Jekyll and Hyde" of organic chemistry allowing for extremely interesting transformations that are not only extremely odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, and this protocol is expected to replace many of the old procedures in the future not only in IMCR but in other areas of organic chemistry as well.

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What this paper is about

Isocyanides are the "Jekyll and Hyde" of organic chemistry allowing for extremely interesting transformations that are not only extremely odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, and this protocol is expected to replace many of the old procedures in the future not only in IMCR but in other areas of organic chemistry as well.

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OpenAlex reports 73 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Isocyanides are the "Jekyll and Hyde" of organic chemistry allowing for extremely interesting transformations that are not only extremely odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, and this protocol is expected to replace many of the old procedures in the future not only in IMCR but in other areas of organic chemistry as well.

Key concepts: Isocyanide, Chemistry, Ugi reaction, Combinatorial chemistry, Computational chemistry, Organic chemistry

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