1979•Journal of General VirologyRequires access

The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

Alan J Hay, N. Kennedy, John James Skehel, Geoffrey Appleyard

Abstract

The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein.

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Key concepts: Amantadine, Virology, Viral matrix protein, Biology, Recombinant DNA, Virus, Gene, Influenza A virus