−1H and −13C NMR Study of C‐16 OYL and C‐17 Acyl Vinblastine Derivatives at 300 MHz Using 2‐D NMR Experiments

Abstract In the present study we describe: (1) the −13C NMR study of two compounds resulting from the amidation of the ester at C‐16 of 17‐deacetyl‐vinblastine and (2) the −1H and −13C NMR study of one compound resulting from the acylation (or esterification) at C‐17 of vinblastine. For the assignment of the −13C NMR resonances, DEPT and −13C, −1H‐heteronuclear shift correlated experiments were performed.