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2011•Journal of the American College of SurgeonsRequires access

A Neurokinin-1 Receptor (NK1R) antagonist (NK-1RA) that reduces postoperative adhesions reduces the adhesion related chemokines CXCL1(KC) and CXCL2 (MIP-2) and their receptor, CXCR2

Hisashi Kosaka, Melanie L. Gainsbury, Holly K. Sheldon, Michael Ryan Cassidy, Arthur F. Stucchi, James M. Becker

Open publisher page 1 citations

Abstract

Postoperative adhesions occur in 90-100% of patients after abdominopelvic surgery. We previously showed that adhesiogenesis is associated with leukocyte migration into the peritoneum and that the NK1R plays an important role in adhesiogenesis. The aim of this study was to characterize the temporal changes and the effects of a NK-1RA on the gene expression of the leukocyte chemoattractants CXCL1 and CXCL2 during adhesiogenesis.

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What this paper is about

Postoperative adhesions occur in 90-100% of patients after abdominopelvic surgery. We previously showed that adhesiogenesis is associated with leukocyte migration into the peritoneum and that the NK1R plays an important role in adhesiogenesis. The aim of this study was to characterize the temporal changes and the effects of a NK-1RA on the gene expression of the leukocyte chemoattractants CXCL1 and CXCL2 during adhesiogenesis.

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Available abstract

Postoperative adhesions occur in 90-100% of patients after abdominopelvic surgery. We previously showed that adhesiogenesis is associated with leukocyte migration into the peritoneum and that the NK1R plays an important role in adhesiogenesis. The aim of this study was to characterize the temporal changes and the effects of a NK-1RA on the gene expression of the leukocyte chemoattractants CXCL1 and CXCL2 during adhesiogenesis.

Key concepts: CXCL2, CXCL1, CXC chemokine receptors, Medicine, Chemokine, Tachykinin receptor 1, Receptor, Receptor antagonist

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A Neurokinin-1 Receptor (NK1R) antagonist (NK-1RA) that reduces postoperative adhesions reduces the adhesion related chemokines CXCL1(KC) and CXCL2 (MIP-2) and their receptor, CXCR2 — Research Paper | ScholarLens