2012•Organic & Biomolecular ChemistryRequires access
The first ratiometric fluorescent probes for aminopeptidase N cell imaging
Laizhong Chen, Wei Sun, Jing Li, Zhenzhen Liu, Zhao Ma, Wei Zhang, Lüpei Du, Wenfang Xu, Hao Fang, Minyong Li
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Abstract
In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed and synthesized, which can be recognized and hydrolyzed by aminopeptidase N (APN) at both the enzymatic and cellular level by following the fluorescent emission wavelength change from blue to green light. As a result, these molecules were successfully identified as the first ratiometric fluorescent probes for APN cell imaging.