1H NMR investigation of supramolecular complex between β-cyclodextrin and cholesterol

A supramolecular complex between β -cyclodextrin and cholesterol was synthesized and characterized via proton 1H NMR spectroscopy. In the supramolecular complex, the stoichiometric proportion of β -cyclodextrin to cholesterol is 1:2. The possible conformation of the supramolecular complex was depicted according to the chemical shift variance of proton 1 H NMR of the host and guest molecules inside the inclusion complex. Removal efficiency of cholesterol complexed by β -cyclodextrin in our work is increased to a remarkable extent. This result can be applied in the field of drug development to reduce cholesterol in blood and other human organs.