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A High-Performance Liquid Chromatographic Method for the Assay of Perphenazine and Its Dealkylated Metabolite in Serum After Therapeutic Doses

Margareta Larsson, Anders Forsman

Abstract

A new high-performance liquid chromatographic method for the assay of perphenazine and its dealkylated metabolite is presented. The procedure is based on the use of thiethylperazine maleate as internal standard. Concentrations of perphenazine and its dealkylated metabolite could be analysed simultaneously in serum from patients being treated with the drug. The intraassay variability was 6.5% and 8.5% and the interassay variability 8.9% and 11.1% for drug and metabolite, respectively.

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Key concepts: Metabolite, Perphenazine, Chromatography, Chemistry, High-performance liquid chromatography, Therapeutic drug monitoring, Pharmacology, Active metabolite