1988•Hormone and Metabolic ResearchRequires access

Effect of Insulin Deficiency on Low Density Lipoprotein Metabolism in Rabbits

A. Golay, L A Zech, M.-Z. Shi, Y.-A. M. Chiou, G M Reaven, Y.-D. I. Chen

Abstract

These studies have been carried out in rabbits with alloxan-induced diabetes in order to see if insulin deficiency affects low density lipoprotein (LDL) catabolism. The results showed that plasma LDL-cholesterol was lower in diabetic rabbits, associated with a fall in the cholesterol to protein ratio of LDL particles. In addition, 125I-LDL disappeared more slowly from plasma of diabetic rabbits, leading to a significant reduction in fractional catabolic rate and a decrease in residence time of 125I-LDL. These data demonstrated that LDL composition and catabolism are greatly altered as a consequence of insulin deficiency.

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Available abstract

Key concepts: Internal medicine, Endocrinology, Catabolism, Diabetes mellitus, Insulin, Metabolism, Cholesterol, Low-density lipoprotein