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Intestinal crypt survival and total and per crypt levels of proliferative cellularity following irradiation: age response and animal lethality.

Ronald F. Hagemann, Samuel W. Lesher

Open publisher page 27 citations

Abstract

Hydroxyurea was employed as a synchronizing agent for proliferative intestinal crypt cells in vivo. The drug was found to kill in excess of 90% of S-phase cells, and to block the G1 to S transition...

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Hydroxyurea was employed as a synchronizing agent for proliferative intestinal crypt cells in vivo. The drug was found to kill in excess of 90% of S-phase cells, and to block the G1 to S transition...

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OpenAlex reports 27 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Hydroxyurea was employed as a synchronizing agent for proliferative intestinal crypt cells in vivo. The drug was found to kill in excess of 90% of S-phase cells, and to block the G1 to S transition...

Key concepts: Crypt, Biology, In vivo, Lethality, Andrology, Toxicology, Endocrinology, Medicine

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Intestinal crypt survival and total and per crypt levels of proliferative cellularity following irradiation: age response and animal lethality. — Research Paper | ScholarLens