Metoclopramide Stimulation of Gastric Motility and Emptying in Diabetic Gastroparesis

Letters1 February 1977Metoclopramide Stimulation of Gastric Motility and Emptying in Diabetic GastroparesisGEORGE F. LONGSTRETH, M.D., JUAN-R. MALAGELADA, M.D., KEITH A. KELLY, M.D.GEORGE F. LONGSTRETH, M.D., JUAN-R. MALAGELADA, M.D., KEITH A. KELLY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-2-195 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with diabetes mellitus are occasionally afflicted by a syndrome of episodic nausea, vomiting, and gastric retention of food generally designated as diabetic gastroparesis (1). Its pathogenesis remains unkown, although autonomic parasympathetic neuropathy may have an important role. Conventional antiemetic therapy is often ineffective, and gastric surgery to promote drainage has failed to produce long-lasting relief. Metoclopramide, a compound structurally related to procainamide, which enhances gastric emptying, may be clinically useful in this condition (1, 2). We have quantified its effects on gastric motility and emptying of an ordinary, solid-liquid meal in a young diabetic patient with severe gastroparesis.A...References1. TETE R and COLLARD N: Gastroparésie et gastroplégia diabétique. La Diabétique:233-24l, 1972 Google Scholar2. BROWNLEE M and KROOPF S: Metoclopramide for gastroparesis diabeticorum. N Engl J Med 291:1257-1258, 1974 CrossrefMedlineGoogle Scholar3. MALAGELADA J, LONGSTRETH G, and SUMMERSKILL W: Measurement of gastric functions during digestion of ordinary solid meals in man. Gastroenterology 70:203-210, 1976 CrossrefMedlineGoogle Scholar4. LONGSTRETH G, MALAGELADA J, and GO V: The gastric response to a transpyloric duodenal tube. Gut 16:777-780, 1975 CrossrefMedlineGoogle Scholar5. METZGER W, CANO R, and STURDEVANT R: Effect of metoclopramide in chronic gastric retention after gastric surgery. Gastroenterology 71:30-32, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE F. LONGSTRETH, M.D.; JUAN-R. MALAGELADA, M.D.; KEITH A. KELLY, M.D.Affiliations: Gastroenterology Unit and Department of Surgery Mayo Clinic and Mayo Foundation Rochester, MN 55901 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byACG Clinical Guideline: GastroparesisRandomised clinical trial: safety, pharmacokinetics and pharmacodynamics of trazpiroben (TAK‐906), a dopamine D 2 /D 3 receptor antagonist, in patients with gastroparesisProkinetic agents for gastroparesisChildhood gastroparesis is a unique entity in need of further investigationMetoclopramide for the treatment of diabetic gastroparesisGastroparesis and Cancer-Related GastroparesisHelping Patients with GastroparesisGastroparesis and Cancer-Related GastroparesisDisorders of gastric EmptyingProkinetics in GastroparesisGastroparesisPathophysiology and pharmacotherapy of gastroparesis: current and future perspectivesClinical Guideline: Management of GastroparesisProkinetic Agents for GastroparesisGastroparesis: Approach, Diagnostic Evaluation, and ManagementMetoclopramide in the treatment of diabetic gastroparesisDiabetic gastroparesis: Therapeutic optionsAmerican Gastroenterological Association technical review on the diagnosis and treatment of gastroparesisPharmacotherapy for intestinal motor and sensory disordersManagement of the Patient with GastroparesisDiabetic Autonomic NeuropathyEvaluation of oral cisapride and metoclopramide in diabetic autonomic neuropathy: an eight-week double-blind crossover studyReview: Overview of Gastrointestinal Disorders Due to Diabetes Mellitus: Emphasis on Nutritional SupportDiabetic GastroparesisAtteinte du tube digestif au cours du diabète: manifestations, traitement et hypothèses pathogéniquesEffect of cisapride on gastric and esophageal emptying in insulin-dependent diabetes mellitusGastroparesis after radiationGastric and oesophageal emptying in insulin-dependent diabetes mellitusDisorders of gastric emptying and the application of radionuclide techniquesSuccessful administration of metoclopramide for the treatment of nausea in patients with advanced liver diseaseAcute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathyEffect of metoclopramide on gastric liquid emptying in patients with diabetic gastroparesisAssessment of gastric motility using meal labeled with technetium-99m sulfur colloidMetoclopramide: Pharmacology and Clinical ApplicationRIYAD ALBIBI, M.D., RICHARD W. 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BOOTH 1 February 1977Volume 86, Issue 2 Page: 195-196 Keywords Diabetes mellitus Food Gastroparesis Nausea Neuropathy Pathogenesis Surgery Vomiting ePublished: 1 December 2008 Issue Published: 1 February 1977 PDF downloadLoading ...