1990•Fundamental and Clinical PharmacologyRequires access

Inhibition of human and rabbit platelet activation by Ketotifen

Philippe Devillier, BERNARD ARNOUX, Chantal Lalau Keraly, Alma Landes, Jean Marsac, Jacques Benveniste

Abstract

The effects of Ketotifen and disodium cromoglycate were investigated on human and rabbit platelet activation. Ketotifen inhibited dose-dependently human and rabbit platelet aggregation. The paf-acether pathway was the most markedly influenced by Ketotifen in human and rabbit platelets (IC50 = 38.8 +/- 7.7 microM and 7.2 +/- 4.5 microM respectively) as compared to adenosine diphosphate (IC50 greater than 100 microM and 79 +/- 19 microM) and to arachidonic acid (IC50 greater than 100 microM and 98 +/- 28 microM). Similar concentrations of Ketotifen inhibited the ATP release from human platelets induced by paf-acether. Disodium cromoglycate up to 5 x 10(-4) M did not inhibit platelet aggregation induced by paf-acether, adenosine diphosphate and arachidonic acid.

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Key concepts: Ketotifen, Platelet, IC50, Platelet-activating factor, Arachidonic acid, Chemistry, Adenosine diphosphate, Pharmacology