P2–229: A preliminary analysis of cerebral amyloid angiopathy (CAA)–related hemorrhage in China

The spontaneous intracerebral hemorrhage (ICH) need toreceive surgical treatment is the most serious and least treatable form of stroke. We aimt o investigate the prevalence of cerebral amyloid angiopathy (CAA) in Chinese patients with spontaneous intracerebral hemorrhage (ICH), who received surgical treatment. Further, to exlpore the connection between low-density lipoprotein receptor related protein-1 (LRP1) and receptor for advanced glycation end products (RAGE), the main receptors for amyloid-beta peptide (Abeta) clearance. Surgical samples of 46 ICH patients from 2010 to 2011 of Nanjing Medical University Affiliated Brain Hospital were enrolled, which included 27 male patients and 19 female patients. The average age was 56±16 yo. The co-expression of Aβ, RAGE and LRP1 protein in the samples were detected by immunohistochemical fluorescence and semi-quantitative analysed. Among 46 cases, 8 patients (17.39%) are diagnosis as CAA by Pathology. The ratio between male and female patients reaches 27: 19 and the positive CAA is 5: 3. Based on the age of onset, patients can be divided into five parts, that is 0% of these patients of younger than 40 years have been confirmed CAA, 10% of the 40 to 49 group, 9.1% of the 50 to 59 group, 23.08% of the 60 to 69 group, the age greater than 70 years old reaching 27.27%. The abnormal proportion of LRP1 protein in patients with ICH achieves the same amount as that of CAA, while there is no unusual expression in non-CAA patients. LRP1 expression is reduced to about 23.03% and RAGE expression is increased to about 32.45%.