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2000•Chinese Journal of Cancer ResearchRequires access

Deletion and 5’CPG island methylation of pl5 gene in brain glioma

Zhai Guang, Xian-hou Yuan, Jin-qing Qi

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Abstract

Objective: To investigate the abnormality of pl5 gene in brain glioma and the correlation of it with occurrence or malignant progression of brain glioma. Methods: Deletion and 5’CPG island methylation of pl5 gene were detected by the methods of PCR and PCR-based methylation in 56 cases of brain glioma. Results: Out of 43 cases of high grade glioma, 14 cases were found to have homozygous deletion of pl5El, while none of the 13 cases of low grade glioma was found to have deletion of pl5El ( P <0.05). Methylation of 5’CPG Island of pl5 gene was found only in four cases of glioma. Conclusion: Abnormality of pl5 gene may involved in the occurrence and malignant progression of brain glioma. Homozygous deletion of gene is the major mechanism of inactivation for pl5 gene in brain glioma.

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What this paper is about

Objective: To investigate the abnormality of pl5 gene in brain glioma and the correlation of it with occurrence or malignant progression of brain glioma. Methods: Deletion and 5’CPG island methylation of pl5 gene were detected by the methods of PCR and PCR-based methylation in 56 cases of brain glioma. Results: Out of 43 cases of high grade glioma, 14 cases were found to have homozygous deletion of pl5El, while none of the 13 cases of low grade glioma was found to have deletion of pl5El ( P <0.05). Methylation of 5’CPG Island of pl5 gene was found only in four cases of glioma. Conclusion: Abnormality of pl5 gene may involved in the occurrence and malignant progression of brain glioma. Homozygous deletion of gene is the major mechanism of inactivation for pl5 gene in brain glioma.

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Available abstract

Objective: To investigate the abnormality of pl5 gene in brain glioma and the correlation of it with occurrence or malignant progression of brain glioma. Methods: Deletion and 5’CPG island methylation of pl5 gene were detected by the methods of PCR and PCR-based methylation in 56 cases of brain glioma. Results: Out of 43 cases of high grade glioma, 14 cases were found to have homozygous deletion of pl5El, while none of the 13 cases of low grade glioma was found to have deletion of pl5El ( P <0.05). Methylation of 5’CPG Island of pl5 gene was found only in four cases of glioma. Conclusion: Abnormality of pl5 gene may involved in the occurrence and malignant progression of brain glioma. Homozygous deletion of gene is the major mechanism of inactivation for pl5 gene in brain glioma.

Key concepts: Glioma, CpG site, Methylation, Gene, DNA methylation, Biology, Cancer research, Genetics

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