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2008•PharmacologyRequires access

Circannual Variations in Carrageenan-Induced Paw Edema and in the Anti-Inflammatory Effect of Phenylbutazone in the Rat

Gaston Labrecque, Pierre M. B eacute langer, Fran ccedil ois Dor eacute

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Abstract

Circannual variation in the edema produced by intraplantar injection of carrageenan (carr) was examined over a period of 31 months. The anti-inflammatory effect of a dose of 30 mg/kg of phenylbutazone (PHZ) was also determined over a period of 1 year. Carr-induced edema was significantly larger in spring while it was smaller in winter. PHZ induced a pronounced reduction of paw edema throughout the year except in spring when the anti-inflammatory effect of the drug could not be detected. Mechanisms responsible for these circannual variations are discussed.

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What this paper is about

Circannual variation in the edema produced by intraplantar injection of carrageenan (carr) was examined over a period of 31 months. The anti-inflammatory effect of a dose of 30 mg/kg of phenylbutazone (PHZ) was also determined over a period of 1 year. Carr-induced edema was significantly larger in spring while it was smaller in winter. PHZ induced a pronounced reduction of paw edema throughout the year except in spring when the anti-inflammatory effect of the drug could not be detected. Mechanisms responsible for these circannual variations are discussed.

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Available abstract

Circannual variation in the edema produced by intraplantar injection of carrageenan (carr) was examined over a period of 31 months. The anti-inflammatory effect of a dose of 30 mg/kg of phenylbutazone (PHZ) was also determined over a period of 1 year. Carr-induced edema was significantly larger in spring while it was smaller in winter. PHZ induced a pronounced reduction of paw edema throughout the year except in spring when the anti-inflammatory effect of the drug could not be detected. Mechanisms responsible for these circannual variations are discussed.

Key concepts: Phenylbutazone, Edema, Carrageenan, Pharmacology, Anti-inflammatory, Anesthesia, Chemistry, Medicine

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Circannual Variations in Carrageenan-Induced Paw Edema and in the Anti-Inflammatory Effect of Phenylbutazone in the Rat — Research Paper | ScholarLens